Calculate dose adjustment for renal impairment using the Dettli method based on CrCl and fraction excreted renally.
Estimated creatinine clearance in mL/min, typically calculated via Cockcroft-Gault equation. Normal is 90-120 mL/min.
(1 - 200)mL/min
The standard dose for a patient with normal renal function. Enter the numeric value only.
mg
The fraction of the drug eliminated unchanged by the kidneys (0 to 1). For example, gentamicin fe = 0.95, vancomycin fe = 0.90, ciprofloxacin fe = 0.65.
(0 - 1)0-1
Standard dosing interval in hours. The calculator may suggest extending this interval for severe renal impairment.
(1 - 72)hours
Results
Dose Adjustment Factor (Q)-
Adjusted Dose-mg
Alternative: Extended Interval-hours
Renal Function Category-
% Normal Elimination-%
References: Dettli method: Q = 1 - fe(1 - KF), where KF = CrCl/120. Dose reduction: Adjusted Dose = Normal Dose x Q. Interval extension: New Interval = Standard Interval / Q. Always consult pharmacokinetic references for specific drugs.